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We have isolated and characterized a novel human and rat organicanion transporter subtype, OATP-D.
2
The effect of probenecid, an inhibitor of organicanion transport, on these measurements was also investigated.
3
Human organicanion transporter hOAT1 plays a critical role in the body disposition of clinically important drugs.
4
Future studies are needed to determine whether these metabolites can serve as qualified biomarkers for organicanion transporters.
5
Phylogenetic tree analysis revealed that OATP-D is branched in a different position from all known organicanion transporters.
1
Background: Nitrate, which is an inorganicanion abundant in vegetables, increases the efficiency of isolated human mitochondria.
2
Nitrate, an inorganicanion abundant in vegetables, is converted in vivo to bioactive nitrogen oxides including NO.
3
Many inorganicanions and several small molecules were investigated as VchCA inhibitors.
4
To obtain detailed information on the reaction processes during ozonation and the resulting oxidation products organic and inorganicanions were analyzed.
Использование термина organic cation на английском
1
Recently, a new family of transporters, named OCT ( organiccation transporters) has been described.
2
These results indicate that the influx transport for amantadine across the BBB involves a proton-coupled organiccation antiporter.
3
Transport rates by organiccation transporters (OCTs) were up to three-fold higher than those of OATs.
4
No significant correlations of valacyclovir pharmacokinetic parameters with PEPT1 and with organiccation or anion transporter expression levels were observed.
5
Because dolutegravir inhibits the renal transporter organiccation transporter 2, reduced tubular secretion of creatinine leads to non-progressive increases in serum creatinine.
6
Here we report that there is significant association between rheumatoid arthritis and the organiccation transporter gene SLC22A4 (P = 0.000034).
7
This phenomenon indicates that the organiccations, which adjust the reaction pH values, can induce different dimensional inorganic frameworks.
8
In ion substitution experiments the current could be carried nonselectively by most cations, including divalent and organiccations, but not by chloride or sulfate ions.
9
Organiccation transporters function primarily in the elimination of cationic drugs, endogenous amines, and other xenobiotics in tissues such as the kidney, intestine, and liver.